Community-based project for education, early detection, and treatment of cervical cancer in Ghana (COM-CAST)
- German-Ghanaian cooperation project within the framework of the African-German Scientific Exchange
- Aim: development of a comprehensive, sustainable, and community-based prevention program for cervical cancer in the western region of Ghana
- Organisation of four bilateral workshops in Ghana and Germany for needs assessment, project structuring, and proposal development
- Transdisciplinary mixed-methods approach in close collaboration with the Ghana Health Service
- Project lead: Prof. Klug (TUM)
- Collaborators: Prof. Sudharsanan, Prof. Winkler, Prof. Okan, Prof. Kiechle (all TUM), Prof. Geldmacher (LMU), Dr. Silling (University of Cologne), Prof. Schmidt (Catholic University of Applied Sciences Munich), Prof. Obiri-Yeboah, Dr. Ken-Amoah, Dr. Akuamoah, Prof. Akakpo (all University of Cape Coast), Ghana Health Service
- Funding: German Research Foundation (DFG)
- Project status: completed
Intervention study to improve participation of non-participants in cervical cancer screening (ROSI)
- Population-based study with 5,000 statutorily insured women who were recruited via an invitation letter from a health insurance fund
- Collection of sociodemographic and health-related factors for the analysis of their association with participation in cervical cancer screening
- Investigation of the acceptance and use of an HPV self-sampling kit among women aged 35 years and older who have not utilised screening in the past five years
- Project lead: Prof. Klug (TUM)
- Collaborators: Statutory health insurance (GKV)
- Funding: German Cancer Aid
- Project status: completed
Incidence of secondary malignant neoplasm and association with therapy of primary cancer (AusTher)
- Estimation of the incidence of second primary malignancies in Germany
- Investigation of the effects of treatment of the primary tumour
- Investigation of additional risk factors for the development of second primary malignancies
- Project lead: Prof. Klug (TUM)
- Collaborators: Centre for Cancer Registry Data (ZfKD)
- Funding: Federal Ministry of Education and Research (BMBF)
- Project status: completed
Publications:
Eberl M, Tanaka LF, Kraywinkel K, Klug SJ. Histology-specific standardized incidence ratio improves the estimation of second primary lung cancer risk. BMC Medicine. 2024; 22(1): 187. doi: 10.1186/s12916-024-03398-9.
Liang LA, Tseng Y-J, Tanaka LF, Klug SJ. Second primary cancer among 217702 colorectal cancer survivors: An analysis of national German cancer registry data. International Journal of Cancer. 2023; 1-13. 153(8):1459-71. doi:10.1002/ijc.34638.
Eberl M, Tanaka LF, Kraywinkel K, Klug SJ. Incidence of Smoking-Related Second Primary Cancers After Lung Cancer in Germany: An Analysis of Nationwide Cancer Registry Data. Journal of Thoracic Oncology. 2022; 17(3):388-98. doi: 10.1016/j.jtho.2021.11.016.
Age indicators and demographic change in Saxony (ADia)
- Secondary data analysis of the official hospital and DRG statistics since 1995 and 2005
- Identification of frequent age-specific diagnoses to visualise the need for medical care
- Illustration of trends in morbidity and demographic development
- Modelling of patient structure with a focus on cancer
- Project lead: PD Dr. Olaf Schoffer (University Hospital Dresden), Prof. Klug (TUM)
- Collaborators: Research Data Centres of the Statistical Offices of the Federation and the Federal States
- Funding: Roland Ernst Foundation for Healthcare
- Project status: completed
Publications:
Schoffer O, Schriefer D, Werblow A, Gottschalk A, Peschel P, Liang LA, Karmann A, Klug SJ. Modelling the effect of demographic change and healthcare infrastructure on the patient structure in German hospitals - A longitudinal national study based on official hospital statistics. BMC Health Services Research. 2023; 23(1): 1081. doi: 10.1186/s12913-023-10056-y.
Schoffer O, Gottschalk A, Liang LA, Werblow A, Schriefer D, Peschel P, Karmann A, Kugler J, Klug SJ. Ranking of the most relevant hospital inpatient diagnoses by age and diagnostic group based on DRG statistics in Germany. Journal of Public Health. 2021; 29(3): 541-51. doi: 10.1007/s10389-019-01155-4.
TP53 Polymorphism Study
- Pooled analysis of original data from 49 studies from 26 countries worldwide to investigate the association of the TP53 codon 72 polymorphism and cervical cancer
- Analysis of 7 946 cases and 7 888 controls
- Meta-analysis of published data from 64 studies worldwide
- Project lead: Prof. Klug (TUM)
- Collaborators: Prof. Blettner (University Medical Centre Mainz)
- Funding: Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
- Project status: completed
Publications:
Klug SJ, Ressing M, Koenig J, Abba MC, Agorastos T, Brenna SM, Ciotti M, Das BR, Del Mistro A, Dybikowska A, Giuliano AR, Gudleviciene Z, Gyllensten U, Haws AL, Helland A, Herrington CS, Hildesheim A, Humbey O, Jee SH, Kim JW, Madeleine MM, Menczer J, Ngan HY, Nishikawa A, Niwa Y, Pegoraro R, Pillai MR, Ranzani G, Rezza G, Rosenthal AN, Roychoudhury S, Saranath D, Schmitt VM, Sengupta S, Settheetham-Ishida W, Shirasawa H, Snijders PJ, Stoler MH, Suárez-Rincón AE, Szarka K, Tachezy R, Ueda M, van der Zee AG, von Knebel Doeberitz M, Wu MT, Yamashita T, Zehbe I, Blettner M. TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies. Lancet Oncology. 2009; 10(8): 772-84. doi: 10.1016/s1470-2045(09)70187-1.