Diabetes Day 2019 at the Karolinska Institute

Our PhD Sander Verbrugge presented our systematic review at the Diabetes Day 2019 at the Karolinska Institute. The topic of our poster was "Genes Whose Gain- or Loss-Of-Function Increases Skeletal Muscle Glucose Uptake in Mice".
More inforamtion you will find in the abstract of the poster: Insulin and exercise increase skeletal muscle glucose uptake, and insulin-mediated glucose uptake is defective in type 2 diabetes patients. To identify genes that regulate glucose uptake in skeletal muscle, we conducted a systematic review to identify genes whose experimental gain- or loss-of-function increases or decreases skeletal muscle glucose uptake in mice. We found that the manipulation of 47 genes increases glucose uptake as measured by accumulation of 2-deoxyglucose in skeletal muscle. The effect size ranged from +10 to +650% and results from the manipulation of the following genes: Slc2a1, Aifm1, Itga2, Ucp3, Cd36, Stk11, Prkcq, Tp53, Trib3, Pik3c3, Igfbp1, Mtor, Igf1r, Cat, Hbegf, Slc2a4, Hk2, Foxc2, Sphk1, Dgat2, Sirt6, Ptpn1, Mapk8, Tbc1d1, Abhd5, Lipa, Txnip, Nos2, Abcc6, Kcna3, Ptpn6, Slc2a12, Timp3, Camk4, Hmga1, Ddah1, Id2, Gnas, Pik3r1, Fasn, Mstn, Cept1, Rxrg, Apob, Il10, Dgat1, Prkag3. Furthermore, we found 40 genes whose gain or loss-of-function decreased glucose uptake in muscle ranging from -15% to -70%. These genes are: Hdac3, Cav3, Irs1, Vegfa, Nob1, Ppargc1a, Agt, Gfpt1, Ptprf, Lpl, Enpp1, Il6, Cpt1c, Sirt1, Tbc1d1, Itgb1, Mmp9, Igf1r, Ankrd26, Insr, Nos3, Igf1r, Inppl1, Stxbp3, Pea15, Ceacam1, Rrad, Tbc1d4, Dgat2, Lnpep, Pparg, Lipe, Dgat1, Rictor, Prkab2, Rab28, Igfbp1, Ptpn11, Igfbp3, Ski. In summary, glucose uptake is a polygenic trait that is influenced by more than 80 genes in mice.