Persistent hyperactivity of the Hippo effector YAP in activated satellite cells is sufficient to cause embryonal rhabdomyosarcoma (ERMS) in mice. In humans, YAP is abundant and nuclear in the majority of ERMS cases, and high YAP expression is associated with poor survival. However, YAP1 is rarely mutated in human ERMS. Instead, the most common mutations in ERMS are oncogenic RAS mutations. Here we compared YAP1 S127A and KRAS G12V-driven rhabdomyosarcomas and re-analysed gene expression microarray datasets from mouse rhabdomyosarcomas caused by these genes. If you want to know more, you can read the full paper here.
New Paper - Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma (copy 1)
Sport- und Gesundheitswissenschaften, W00BBR-newscat-exercisebiology |
