On Friday the 23rd of November, the Symposium “Fighting muscle weakness when we get old” took place at the Lithuanian Sports University in Kaunas. This symposium were hold the first time on the topic of Sarcopenia which is a disease increasing in aging societies. Together, Aivaras Ratkevicius and… [weiterlesen]

The main focus of the TUM Exercise Biology Group is to identify molecular mechanisms of adaptation by which exercise training improves our fitness and health. We are particularly focussed on the so-called Hippo proteins as these proteins respond to exercise-associated stimuli and regulate… [weiterlesen]

Persistent hyperactivity of the Hippo effector YAP in activated satellite cells is sufficient to cause embryonal rhabdomyosarcoma (ERMS) in mice. In humans, YAP is abundant and nuclear in the majority of ERMS cases, and high YAP expression is associated with poor survival. However, YAP1 is rarely… [weiterlesen]

Higher levels of physical activity are associated with a lower risk of developing cancer and exercise interventions in cancer patients have several beneficial effects including potential anti-cancer effects. The mechanisms by which physical activity or exercise prevents cancer or influences an… [weiterlesen]

One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that occurs in response to resistance exercise. A large body of work shows that a mTORC1-mediated increase of muscle protein synthesis is the key, but not sole. Whilst much of the hypertrophy signaling cascade has… [weiterlesen]